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Rectal25 mg administered rectally onceThis dose may be repeated every 4 hours as needed.

This product relieves apprehension and induces a quiet sleep from which the patient can be easily arousedAdministration of 12.5 to 25 mg promethazine hydrochloride by the oral route or by rectal suppository at bedtime will provide sedation in childrenAdults usually require 25 to 50 mg for nighttimepresurgicalor obstetrical sedation.

Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine HClpromethazine hydrochlorideThese doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subjectdepending upon the indication for which the drug is prescribedDaily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in ratsSpecific studies to test the action of the drug on parturitionlactationand development of the animal neonate were not donebut a general preliminary study in rats indicated no effect on these parametersAlthough antihistamines have been found to produce fetal mortality in rodentsthe pharmacological effects of histamine in the rodent do not parallel those in manThere are no adequate and well-controlled studies of promethazine hydrochloride tablets in pregnant women.

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phenylephrine, promethazine major sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly.